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L-citrulline is an amino acid found in watermelon. It is also made in the body. The body changes L-citrulline into another amino acid called L-arginine. The name citrulline comes from Citrullus vulgaris, the Latin term for watermelon

Possibly Effective for

  • Athletic performance. Taking L-citrulline by mouth might help improve some types of exercise performance such as weight lifting. But its effects on aerobic exercises such as running are unclear.

There is interest in using L-citrulline for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.